The Wong Lab

Single-molecule Force Studies

 
 

Our group studies how biological systems work at the nanoscale, and the physical laws that govern their behavior. We are particularly interested in the weak, non-covalent interactions between and within biological molecules (e.g. base-pairing in nucleic acids, receptor-ligand bonding, protein folding, etc.), and the coupling of these interactions to mechanical force. To investigate these issues, we develop and apply novel techniques in single-molecule manipulation, detection, and analysis, including optical tweezers methods and high-resolution optical detection.


Please take a look around our website to learn more. Read more about our research, learn about our members, peruse our publications, find out about new happenings in our group, or click here to contact us.


Our group is part of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and the Program in Cellular and Molecular Medicine at Boston Children’s Hospital, and the Wyss Institute for Biologically Inspired Engineering at Harvard University.


We acknowledge support from the NIH NIGMS, the Arnold and Mabel Beckman Foundation, the American Heart Association, Takeda New Frontier Science, Agilent Technologies, Boston Children’s Hospital, and the Wyss Institute for Biologically Inspired Engineering.

 


Welcome to the Wesley P. Wong Lab at Harvard

Our group develops and applies new techniques in single-molecule manipulation to study biological systems at the nanoscale.